Nonsensical plot, garbled writing, Val Kilmer at peak vain actor jerkhood, David Thewlis playing a weak-willed and barely tolerable hero, Marlon Brando being an insane, muumuu-clad nightmare (on-screen and off), and a supporting cast buried in disgustingly thick makeup to make them look like human-animal hybrids. It's hard to watch, both because of technical decisions, and because of the human element of watching a total trainwreck. It's glorious. It's hideous. It's neither the Island of Dr. Moreau we need nor deserve, but like the hybrid creatures the titular character is so proud of, it's the product we are stuck with.
I highly recommend the rifftrax that accompanies the movie and once you finish, give the How Did this Get made podcast episode for this movie a listen. Together they go a long way in redeeming and explaining what the hell this monstrosity even is.
This is Ron Perlman.